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Gold nephropathy

T T Antonovych

    Annals of Clinical and Laboratory Science
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Gold salts, or chrysotherapy, effectively treat rheumatoid arthritis but can cause kidney damage. Identifying gold inclusions (aurosomes) in kidney cells confirms this toxicity.

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    Area of Science:

    • Medical History
    • Pharmacology
    • Nephrology

    Background:

    • Gold compounds have a long history in medicine, notably used for tuberculosis and later for rheumatoid arthritis and lupus erythematosus.
    • Chrysotherapy, gold salt treatment, has been a primary therapy for rheumatoid arthritis for 50 years due to its efficacy.
    • Gold salt toxicity is a concern, with potential adverse effects including skin reactions, bone marrow suppression, and significant nephrotoxicity.

    Purpose of the Study:

    • To review the historical use of gold in medicine.
    • To discuss the mechanisms and manifestations of gold-induced nephrotoxicity.
    • To highlight diagnostic methods for confirming gold-related kidney damage.

    Main Methods:

    • Review of historical medical literature on gold therapy.

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  • Analysis of clinical and pathological findings in gold-treated patients with renal complications.
  • Discussion of diagnostic techniques for detecting gold deposits in renal tissues.

    • Main Results:

    • Gold salts, while effective for rheumatoid arthritis, can lead to serious kidney issues like renal insufficiency, proteinuria, hematuria, and nephrotic syndrome.
    • Pathological changes in the kidneys include tubular degeneration, acute tubular necrosis, and immune complex glomerulonephritis.
    • The presence of gold inclusions (aurosomes) in proximal tubular cells is a key diagnostic marker for gold nephrotoxicity.

    Conclusions:

    • Chrysotherapy remains a valuable treatment for rheumatoid arthritis but requires careful monitoring for renal side effects.
    • Accurate diagnosis of gold nephrotoxicity relies on correlating clinical symptoms with pathological evidence, particularly the presence of aurosomes.
    • Understanding the pathogenic mechanisms of gold-induced kidney damage is crucial for patient management and developing safer therapeutic strategies.