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[Increased effectiveness of antibiotic therapy with adaptogens in dysentery and Proteus infection in children]
Insights
Adaptogens like Eleuterococcus significantly shortened illness duration in children with bacterial infections. Combining adaptogens with antibiotics enhanced treatment efficacy for dysentery and Proteus infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Acute dysentery and Proteus enterocolitis are significant childhood infections.
- Understanding host immunological reactivity is crucial for effective treatment.
- Antibiotic resistance necessitates exploring complementary therapies.
Purpose of the Study:
- To evaluate the impact of adaptogens on the course of dysentery and Proteus infections in children.
- To assess the influence of adaptogens on host immunological markers.
- To determine if adaptogens enhance antibiotic therapy efficacy.
Main Methods:
- Studied 258 children (0-14 years) with acute dysentery (Shigella) or Proteus enterocolitis.
- Group 1 (157 patients): Treated with monomycin and kanamycin plus adaptogens (Eleuterococcus, Echinopanax elatum).
- Group 2 (101 patients): Treated with antibiotics alone.
Main Results:
- Adaptogen use was associated with decreased disease duration.
- Immunological parameters (IgA, IgM, IgG titers, bactericidal properties) were monitored.
- Children receiving adaptogens showed improved treatment outcomes.
Conclusions:
- Adaptogens, such as Eleuterococcus, enhance the efficacy of antibiotic treatment in pediatric patients.
- Integrating adaptogens into therapy can shorten illness periods for Shigella and Proteus infections.
- Adaptogen use represents a promising strategy to improve outcomes in pediatric infectious gastroenteritis.
Abstract:
The course of the disease and the host immunological reactivity (IgA, IgM, IgG, CPhI, IgG and IgM antibody titers in the HIT, blood bactericidic properties) were studied in 258 children aged 0 to 14 year suffering from acute dysentery caused by Shigella sonnei and flexneri and enterocolitis of the Proteus etiology. 157 patients were treated with monomycin and kanamycin in combination with adaptogens, such as Eleuterococcus and Echinopanax elatum Nakai L. and 101 patients were treated with the antibiotics alone. It was shown that the use of the adaptogens decreased the periods of the diseases. It is concluded that adaptogens increase the efficacy of antibiotic therapy in children with dysentery and Proteus infection.