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Related Experiment Videos

Propranolol in experimentally induced stress

E A Taylor, J Harrison, P Turner

    The British Journal of Psychiatry : the Journal of Mental Science
    |December 1, 1981
    PubMed
    Summary

    Beta-blocker propranolol significantly reduced stress-induced increases in heart rate and blood pressure in healthy volunteers. However, subjective feelings of anxiety and concentration remained unaffected by the medication.

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    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology
    • Stress Response

    Background:

    • Beta-adrenoceptor antagonists, like propranolol, are widely used for cardiovascular conditions.
    • The impact of these drugs on physiological and psychological responses to acute stress requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of beta-adrenoceptor antagonism on physiological and psychological responses to experimental stress.

    Main Methods:

    • A double-blind, placebo-controlled study involving 12 healthy volunteers.
    • Administration of a single oral dose of 80 mg propranolol versus placebo.
    • Measurement of heart rate, systolic and diastolic blood pressure, skin temperature, and self-reported anxiety, alertness, and concentration during stress.

    Main Results:

    • Propranolol significantly attenuated stress-induced increases in heart rate (49.9% vs 61.0%) and systolic blood pressure (8.3% vs 17.4%) compared to placebo.
    • A significant reduction in trunk skin temperature rise was observed with propranolol.
    • No significant differences were found in self-rated anxiety, alertness, or concentration between propranolol and placebo groups.

    Conclusions:

    • Beta-adrenoceptor blockade with propranolol effectively mitigates key physiological stress responses, including heart rate and blood pressure elevation.
    • Propranolol does not appear to influence subjective psychological states like anxiety or cognitive functions such as concentration during acute stress in healthy individuals.

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