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The vitamin D system: a view from basic science to the clinic

H F Deluca

    Clinical Biochemistry
    |October 1, 1981
    PubMed
    Summary

    The vitamin D endocrine system regulates calcium and phosphorus for bone health. Understanding this system aids in diagnosing and treating metabolic bone diseases like osteoporosis.

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    A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

    Analytical biochemistry·1992

    Area of Science:

    • Endocrinology
    • Metabolic Bone Disease

    Background:

    • Vitamin D requires metabolic activation to become a functional hormone.
    • This hormone is crucial for calcium and phosphorus mobilization, supporting bone development and neuromuscular function.
    • The vitamin D endocrine system regulates calcium and phosphate homeostasis.

    Purpose of the Study:

    • To elucidate the role of the vitamin D endocrine system in calcium and phosphate metabolism.
    • To highlight the significance of this system in bone health and neuromuscular function.
    • To emphasize the diagnostic and therapeutic implications of understanding vitamin D metabolism.

    Main Methods:

    • The abstract describes the metabolic pathway and hormonal regulation of vitamin D.
    • It outlines the mechanism of action of the vitamin D hormone.
    • It discusses the role of the parathyroid gland in regulating vitamin D hormone production.

    Main Results:

    • The vitamin D hormone, produced in the kidney, stimulates calcium and phosphorus mobilization from the intestine, bone, and kidney.
    • This hormonal action is essential for normal bone development and neuromuscular function.
    • The parathyroid hormone stimulates the production of the vitamin D hormone in response to calcium needs.

    Conclusions:

    • The vitamin D endocrine system is vital for calcium and phosphate homeostasis.
    • Disturbances in this system are linked to various metabolic bone diseases.
    • Measuring vitamin D hormone levels is valuable for diagnosing metabolic bone diseases, and new vitamin D compounds offer therapeutic potential.

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