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Amoxapine (Asendin, Lederle Laboratories)

J E Dugas, S S Weber

    Drug Intelligence & Clinical Pharmacy
    |March 1, 1982
    PubMed
    Summary

    Amoxapine, a tricyclic antidepressant, shows effectiveness comparable to other agents like amitriptyline for depression symptoms. However, more research is needed to confirm its superiority and establish its place in treatment.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Psychiatry

    Background:

    • Amoxapine is a tricyclic antidepressant structurally related to loxapine.
    • It selectively blocks norepinephrine reuptake, similar to desipramine.

    Purpose of the Study:

    • To evaluate the efficacy and therapeutic potential of amoxapine in treating depressive illnesses.
    • To identify the need for further comparative studies with similar antidepressants.

    Main Methods:

    • Review of existing studies on amoxapine's efficacy in patients with mixed depressive illnesses.
    • Analysis of available biopharmaceutical, pharmacokinetic, and toxicity data.

    Main Results:

    • Amoxapine demonstrated efficacy comparable to amitriptyline and imipramine, and superior to placebo.
    • Data supporting rapid onset of effects are based on small, heterogeneous patient samples.
    • Limited data exist on pharmacokinetics, serum concentration-efficacy relationships, acute toxicity, and drug interactions.

    Conclusions:

    • Amoxapine serves as a chemical alternative to traditional tricyclic antidepressants.
    • No consistent data show amoxapine's superiority over other antidepressants for specific symptoms or populations.
    • Further studies comparing amoxapine with similar agents in homogeneous groups are required.

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