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Diseases associated with immunosuppression

E R Heise

    Environmental Health Perspectives
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clinical immunodeficiency arises from defects in immune system components like T-cells and B-cells, leading to increased susceptibility to infections and higher risks of malignancy and autoimmune diseases.

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    Area of Science:

    • Immunology
    • Clinical Medicine

    Background:

    • Impairment of major immune components (T-cells, B-cells, phagocytes, complement) causes clinical immunodeficiency.
    • Defects can be intrinsic, heritable, due to failed differentiation, viral infection, or acquired.
    • Clinical manifestations include susceptibility to pathogens, increased malignancy risk, allergies, and autoimmune diseases.

    Purpose of the Study:

    • To discuss the basic defects of primary and secondary immunodeficiencies.
    • To relate these defects to observed immunologic consequences.
    • To highlight the unique infection patterns associated with different immune deficiency types.

    Main Methods:

    • Review of primary and secondary immunodeficiency disorders.
    • Discussion of underlying immunologic defects.

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  • Correlation of defects with clinical and immunological outcomes.

    • Main Results:

    • Identified major immune components whose impairment leads to immunodeficiency.
    • Characterized diverse causes of immune defects, including genetic and acquired factors.
    • Linked specific immune defects to patterns of infection and associated diseases like malignancy and autoimmunity.

    Conclusions:

    • Immunodeficiency results from defects in key immune system parts, leading to varied clinical presentations.
    • Understanding the level and mechanism of the defect is crucial for predicting infection patterns.
    • Aberrant immune regulation is a feature of certain immunodeficiency disorders.