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Related Experiment Videos

Changes in active and inactive renin throughout pregnancy

W A Hsueh, J A Luetscher, E J Carlson

    The Journal of Clinical Endocrinology and Metabolism
    |May 1, 1982
    PubMed
    Summary

    During pregnancy, inactive renin levels surge significantly, while active renin also increases initially. Changes in sodium intake affect both, suggesting kidney involvement in altered plasma renin during gestation.

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    Area of Science:

    • Reproductive Endocrinology
    • Renal Physiology

    Background:

    • Plasma renin concentrations undergo significant alterations during pregnancy.
    • Understanding the behavior of active and inactive renin is crucial for reproductive health.

    Purpose of the Study:

    • To characterize the changes in active and inactive renin during pregnancy.
    • To investigate the molecular weight and source of renin in pregnancy plasma.

    Main Methods:

    • Plasma and amniotic fluid analysis for active and inactive renin concentrations.
    • Molecular weight estimation using gel filtration chromatography (Sephadex G-100, Sephacryl S-200).
    • Assessment of renin response to sodium intake variations.

    Main Results:

    • Inactive renin rapidly increases in early pregnancy, with consistent molecular weight in plasma.

    Related Experiment Videos

  • Amniotic fluid inactive renin shows anomalous molecular weight behavior.
  • Active renin increases modestly in early pregnancy, with a larger apparent molecular weight in pregnancy plasma.
  • Renin concentration changes parallel non-pregnant responses to sodium intake.

    • Conclusions:

    • The kidneys are a likely source of altered plasma renin during pregnancy.
    • Angiotensinogen plays a key role in maintaining elevated plasma renin activity in late pregnancy.
    • Anomalous molecular weight findings for amniotic fluid inactive renin require further investigation.