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[Triamterene induced nephrolithiasis (author's transl)]
Journal D'Urologie
|January 1, 1982
Summary
Regular use of triamterene can lead to kidney stone formation. Stones analyzed contained significant amounts of triamterene and its metabolite, highlighting drug-induced nephrolithiasis risks.
Area of Science:
- Nephrology
- Pharmacology
- Urology
Background:
- Nephrolithiasis is associated with certain drug consumptions.
- Triamterene is a diuretic medication with potential renal effects.
Observation:
- Five case studies analyzed patients consuming normal doses of triamterene.
- Renal stones were analyzed using infra-red spectrophotometry.
Findings:
- Triamterene and its metabolite, hydroxytriamterene, were found in renal stones (20-100%).
- These compounds are poorly soluble, causing urine supersaturation post-ingestion.
- Triamterene may play a role in the initial nucleation of kidney stones.
Implications:
- Caution is advised when prescribing triamterene to patients with a history of nephrolithiasis.
- Drug-induced nephrolithiasis underscores the importance of renal stone analysis.
- Systematic stone analysis is crucial for understanding correlations between treatments and stone disease.