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Hypoglycemia during prolonged exercise in normal men

P Felig, A Cherif, A Minagawa

The New England Journal of Medicine

|April 15, 1982

Summary

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Hypoglycemia, or low blood glucose, can occur in healthy men during prolonged exercise. This condition leads to an exaggerated epinephrine response but does not significantly impact endurance or delay exhaustion.

Area of Science:

Exercise Physiology
Metabolic Regulation

Background:

Hypoglycemia is defined as blood glucose levels below 45 mg/dL.
Prolonged strenuous exercise can challenge glucose homeostasis.

Purpose of the Study:

To investigate the occurrence and effects of exercise-induced hypoglycemia in healthy men.
To examine the relationship between blood glucose, plasma epinephrine, and endurance during exhaustive exercise.

Main Methods:

Healthy men exercised to exhaustion on a cycle ergometer at 60-65% maximal aerobic power.
Blood glucose and plasma epinephrine levels were monitored.
The effects of glucose ingestion on these parameters and endurance were assessed.

Main Results:

Hypoglycemia (blood glucose < 45 mg/dL) occurred in 7 of 19 subjects.

Related Experiment Videos

Hypoglycemic subjects exhibited significantly higher plasma epinephrine levels.

Glucose ingestion prevented hypoglycemia and blunted epinephrine response but did not consistently improve endurance.

Conclusions:

Exercise-induced hypoglycemia is a potential occurrence in healthy individuals during prolonged exertion.
Hypoglycemia is associated with an exaggerated epinephrine response.
Despite causing hypoglycemia, low blood glucose levels do not appear to limit endurance performance in this population.