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Drug therapy considerations in the elderly

R A Herman

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |April 10, 1982
    PubMed
    Summary

    As people age, changes in how the body processes drugs can lead to problems. This review covers age-related pharmacological factors and suggests better drug treatments for older adults.

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    Area of Science:

    • Gerontology
    • Clinical Pharmacology
    • Pharmacokinetics

    Background:

    • The elderly population is growing, leading to increased prescription drug use.
    • Drug therapy in older adults presents unique challenges.
    • Age-related physiological changes can significantly impact drug efficacy and safety.

    Purpose of the Study:

    • To review age-related changes in pharmacokinetic and pharmacodynamic processes.
    • To discuss how these changes affect drug action in the elderly.
    • To provide recommendations for optimizing drug therapy in older patients.

    Main Methods:

    • Literature review of pharmacological factors influencing drug action with age.
    • Analysis of age-associated alterations in absorption, distribution, metabolism, and excretion.
    • Examination of changes in receptor sensitivity and homeostatic mechanisms.

    Main Results:

    • Aging alters drug absorption, distribution, metabolism, and excretion.
    • Changes in tissue localization and receptor sites affect drug responses.
    • Homeostatic mechanisms become less efficient, impacting drug safety.

    Conclusions:

    • Pharmacological management in the elderly requires careful consideration of age-related changes.
    • Adjusting drug dosages and choices is crucial for safe and effective treatment.
    • Further research into geriatric pharmacotherapy is warranted.

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