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Aprindine-induced polymorphous ventricular tachycardia

D Scagliotti, B Strasberg, H A Hai

    The American Journal of Cardiology
    |April 1, 1982
    PubMed
    Summary
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    Aprindine can cause dangerous heart rhythm problems, specifically polymorphous ventricular tachycardia (also known as torsade de pointes). Discontinuing the drug typically resolves this serious side effect.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Electrophysiology

    Background:

    • Aprindine is an antiarrhythmic medication.
    • Polymorphous ventricular tachycardia (torsade de pointes) is a potentially life-threatening arrhythmia.
    • Drug-induced arrhythmias are a significant concern in clinical practice.

    Observation:

    • This study reports five cases of polymorphous ventricular tachycardia (torsade de pointes) potentially linked to aprindine use.
    • In four cases, the arrhythmia occurred after oral administration of 400 mg aprindine.
    • One patient presented with mild hypokalemia, complicating direct causality assessment.

    Findings:

    • All five patients exhibited Q-T interval prolongation.
    • Recurrent syncope was a common symptom in affected individuals.

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  • Polymorphous ventricular tachycardia resolved in all cases upon aprindine discontinuation.

    • Implications:

    • Aprindine may induce torsade de pointes, characterized by Q-T prolongation and syncope.
    • Careful patient monitoring is crucial when prescribing aprindine.
    • Discontinuation of aprindine is an effective treatment for this adverse cardiac event.