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Related Experiment Videos

Perinatal group B streptococcal colonization and infection

J G Allardice, T F Baskett, M M Seshia

    American Journal of Obstetrics and Gynecology
    |March 15, 1982
    PubMed
    Summary

    Antenatal screening and labor treatment for vaginal group B streptococcus colonization significantly reduce infant infections. This approach lowers neonatal colonization and prevents serious infections and fatalities in newborns.

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    Placenta·2011

    Area of Science:

    • Obstetrics and Gynecology
    • Neonatal Health
    • Infectious Disease Prevention

    Background:

    • Group B Streptococcus (GBS) colonization is a significant concern during pregnancy.
    • Neonatal GBS infection can lead to severe morbidity and mortality.
    • Effective screening and treatment strategies are crucial for maternal and infant health.

    Purpose of the Study:

    • To evaluate the effectiveness of antenatal screening and intrapartum treatment for vaginal GBS colonization.
    • To determine the impact of GBS treatment on neonatal colonization and infection rates.
    • To assess the reduction in GBS-related neonatal morbidity and mortality.

    Main Methods:

    • Screening of 2,169 laboring patients for vaginal GBS colonization.
    • Antenatal screening of 524 patients for GBS.

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  • Intravenous ampicillin treatment for 57 GBS-positive patients during labor.
  • Comparison of outcomes between treated and untreated GBS-colonized mother-infant pairs.

    • Main Results:

    • 7.6% of screened laboring patients were GBS-positive (164/2169).
    • No infections occurred in infants born to treated mothers (0/4 colonized infants).
    • In untreated GBS-positive mothers, 62 neonates were colonized, nine became infected, and three died (6.6% attack rate).

    Conclusions:

    • Antenatal screening combined with intrapartum GBS treatment effectively reduces neonatal colonization.
    • This strategy significantly decreases the incidence of neonatal GBS infection and associated mortality.
    • Implementing GBS screening and treatment protocols is vital for improving neonatal outcomes.