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Functional capillary density in normal and transplanted rat hearts

B Korecky, C M Hai, K Rakusan

    Canadian Journal of Physiology and Pharmacology
    |January 1, 1982
    PubMed
    Summary
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    Hypoxemia (low oxygen) causes subepicardial capillary recruitment in beating rat hearts, reducing intercapillary distance. This effect is linked to postnatal development and not optical artifacts.

    Area of Science:

    • Cardiovascular Physiology
    • Microcirculation Research
    • Hypoxia Studies

    Background:

    • Understanding capillary dynamics is crucial for oxygen delivery to the myocardium.
    • Previous studies suggest capillary recruitment occurs under hypoxic conditions.

    Purpose of the Study:

    • To investigate the effect of hypoxemia on subepicardial capillary functional intercapillary distance (ICD) in beating rat hearts.
    • To determine if capillary recruitment under hypoxemia is influenced by postnatal development.
    • To rule out optical artifacts as a cause for observed changes in ICD.

    Main Methods:

    • Cinemicrophotography of beating rat hearts under normoxemia and hypoxemia.
    • Direct measurement of functional intercapillary distances (ICD) from focused frames.

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  • Analysis of ICD changes during postnatal development and in heterotopically transplanted hearts.

    • Main Results:

    • Hypoxemia significantly decreased average ICD from 19.2 to 17.9 micrometers, indicating capillary recruitment.
    • This recruitment corresponded to an increase of 416 capillaries/mm².
    • Both normoxemic and hypoxemic ICDs increased with left ventricular weight during postnatal development, with hypoxemic ICDs remaining shorter.
    • No difference in ICD was observed between normoxemia and hypoxemia in heterotopically transplanted hearts, regardless of imaging magnification.

    Conclusions:

    • Hypoxemia induces functional capillary recruitment in the subepicardium of in situ beating rat hearts.
    • Capillary recruitment is influenced by developmental factors and remains significant even with increasing heart size.
    • The observed recruitment is a genuine physiological response and not an artifact of imaging techniques or optical properties.