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Chronic urticaria Investigations with patch and challenge tests

R P Warin, R J Smith

    Contact Dermatitis
    |March 1, 1982
    PubMed
    Summary
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    Immediate patch tests may help identify chronic urticaria triggers. Balsam of Peru and cinnamon frequently caused reactions in normal subjects, with cinnamon and cloves confirmed as allergens in some patients.

    Area of Science:

    • Dermatology
    • Allergology

    Background:

    • Chronic urticaria (CU) is a common dermatological condition.
    • Identifying specific triggers for CU can be challenging.

    Purpose of the Study:

    • To evaluate the utility of immediate patch testing in diagnosing chronic urticaria.
    • To investigate the immediate weal response to various substances in CU patients.

    Main Methods:

    • 56 patients with chronic urticaria underwent patch testing.
    • Immediate weal responses were recorded for multiple substances.
    • Challenge tests were performed for substances with positive immediate reactions.

    Main Results:

    • Balsam of Peru and cinnamon frequently elicited positive immediate patch tests, often in normal subjects.

    Related Experiment Videos

  • Positive challenge tests occurred in two patients for cinnamon and two for cloves, following positive immediate patch tests.
  • Nickel showed positive immediate patch tests in 4 patients and positive 48-hour patch tests in 3 patients, but no positive challenge tests.

    • Conclusions:

    • Immediate patch testing may offer value in investigating chronic urticaria, particularly for substances like cinnamon and cloves.
    • Further research is needed to identify additional allergens that elicit immediate reactions in chronic urticaria.