Bone marrow transplantation for hematologic malignancies

Allogeneic and syngeneic bone marrow transplantation has developed into an important treatment for hematologic malignancies such as acute myelogenous or lymphoblastic leukemia, chronic granulocytic leukemia in accelerated phase, acute malignant myelosclerosis, and various forms of lymphoma. So far, more than 500 patients with these disorders have been transplanted at centers throughout the world. Marrow transplantation is still surrounded by several significant clinical problems. However, optimal results are obtained when marrow grafting is performed early during the clinical course of the respective disorders.