Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gangrenous and crepitant cellulitis

D S Feingold

    Journal of the American Academy of Dermatology
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This review covers dangerous soft tissue infections with gangrene or tissue gas. It details their characteristics, diagnosis, and treatment for better patient outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Atlas of infections of the skin.

    Archives of dermatology·2014
    Same author

    The mechanism of colicin E 1 action.

    The Journal of membrane biology·2013
    Same author

    Locus of the catalytic sites of udp-glucose dehydrogenase in the native enzyme hexamer as delineated by fluorescence energy transfer.

    Biophysical journal·2009
    Same author

    Benign familial pemphigus (Hailey-Hailey disease). Treatment with the pulsed carbon dioxide laser.

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1998
    Same author

    Once-weekly fluconazole (150, 300, or 450 mg) in the treatment of distal subungual onychomycosis of the toenail.

    Journal of the American Academy of Dermatology·1998
    Same author

    Pharmacokinetics of three doses of once-weekly fluconazole (150, 300, and 450 mg) in distal subungual onychomycosis of the toenail.

    Journal of the American Academy of Dermatology·1998

    Area of Science:

    • Infectious Diseases
    • Surgical Pathology
    • Microbiology

    Background:

    • Soft tissue infections (STIs) encompass a spectrum of microbial invasions affecting skin, subcutaneous tissue, fascia, and skeletal muscle.
    • A subset of STIs presents with extensive tissue necrosis (gangrene) and/or gas formation within tissues, indicating a severe and rapidly progressive process.
    • These specific infections, often termed necrotizing soft tissue infections (NSTIs), pose significant diagnostic and therapeutic challenges due to their high morbidity and mortality.

    Purpose of the Study:

    • To review the key identifying characteristics of STIs involving gangrene and/or tissue gas.
    • To outline current diagnostic measures for accurately identifying these dangerous infections.
    • To discuss established and emerging therapeutic strategies for managing patients with these severe conditions.

    Related Experiment Videos

    Main Methods:

    • Literature review of existing studies on soft tissue infections with gangrene and/or tissue gas.
    • Analysis of diagnostic criteria and imaging modalities used for early detection.
    • Synthesis of treatment guidelines, including surgical debridement, antimicrobial therapy, and supportive care.

    Main Results:

    • These infections are characterized by rapid progression, extensive tissue destruction, and potential systemic toxicity.
    • Early recognition relies on clinical signs of severe inflammation, pain out of proportion to findings, and imaging evidence of gas.
    • Prompt surgical intervention combined with broad-spectrum antibiotics is crucial for survival.

    Conclusions:

    • Necrotizing soft tissue infections represent a critical surgical emergency requiring immediate recognition and aggressive management.
    • Multidisciplinary approaches involving infectious disease specialists, surgeons, and radiologists are essential for optimal patient outcomes.
    • Continued research into novel diagnostic markers and therapeutic agents is warranted to improve the management of these devastating infections.