Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormones and renin secretion

W F Ganong

    Life Sciences
    |February 15, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The pituitary gland influences renin secretion, with its absence initially potentiating responses but later abolishing them, possibly due to reduced thyroid function impacting beta-adrenergic activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Circumventricular organs: definition and role in the regulation of endocrine and autonomic function.

    Clinical and experimental pharmacology & physiology·2000
    Same author

    Angiotensin II receptor binding sites in the ventral portion of the bed nucleus of the stria terminalis are reduced by interruption of the medial forebrain bundle.

    Brain research·1998
    Same author

    Coda. Tissue renin-angiotensin systems, 1994.

    Advances in experimental medicine and biology·1995
    Same author

    Reproduction and the renin-angiotensin system.

    Neuroscience and biobehavioral reviews·1995
    Same author

    Anencephaly and other neural tube defects.

    Frontiers in neuroendocrinology·1994
    Same author

    What regulates the production and secretion of angiotensinogen in the brain?

    Frontiers in neuroendocrinology·1994
    Same journal

    Corrigendum to "Adipose stem cells-derived microvesicles and chicken egg-derived exosomes attenuate cardiac ischemia/reperfusion injury through AKT/ERK/Nrf2/HO-1 axis to inhibit apoptosis and inflammation and restore autophagy" [Life Sci. 395 (2026) 124364].

    Life sciences·2026
    Same journal

    MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

    Life sciences·2026
    Same journal

    TNF-centered network pharmacology and molecular modeling of selected Andrographis paniculata compounds in hypertension.

    Life sciences·2026
    Same journal

    Retraction notice to "Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat" [Life Sci. 113 (2014) 22-30].

    Life sciences·2026
    Same journal

    Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

    Life sciences·2026
    Same journal

    METTL1 promotes hepatic steatosis by mediating m<sup>7</sup>G modification of ALOX15B mRNA.

    Life sciences·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Renal Physiology

    Background:

    • Circulating angiotensin II is primarily formed by renin acting on angiotensinogen.
    • Intracellular renin-angiotensin systems exist in various tissues, including juxtaglomerular cells and neurons.
    • Renin secretion is regulated by multiple factors, including sympathetic nervous system activity and hormonal influences.

    Purpose of the Study:

    • To investigate the role of the pituitary gland in regulating renin secretion.
    • To explore the impact of hypophysectomy on the renin response to p-chloroamphetamine.
    • To examine the potential link between pituitary function, thyroid activity, and beta-adrenergic regulation of renin.

    Main Methods:

    • Investigated the effect of hypophysectomy on the renin response to p-chloroamphetamine in animal models.

    Related Experiment Videos

  • Assessed renin secretion at different time points following pituitary removal.
  • Correlated changes in renin response with potential alterations in thyroid function and beta-adrenergic activity.

    • Main Results:

    • Immediately after hypophysectomy, the renin response to p-chloroamphetamine was potentiated.
    • Twenty-two days post-hypophysectomy, this renin response was abolished.
    • The delayed loss of responsiveness suggests a slowly developing effect, potentially linked to decreased thyroid function.

    Conclusions:

    • The pituitary gland plays a crucial, time-dependent role in modulating the renin response to certain stimuli.
    • Hypothyroidism, possibly secondary to pituitary dysfunction, may contribute to decreased plasma renin activity.
    • These findings highlight complex interactions between the pituitary, thyroid, and sympathetic nervous system in regulating the renin-angiotensin system.