Report on various clinical studies on high dose methotrexate in Europe (non EORTC)
Related Experiment Video
Updated: Oct 24, 2026

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)
Published on: June 9, 2026
Abstract:
High dose Methotrexate (HDMtx) is used in the therapy of a broad variety of human tumors. This review reports on completed, ongoing, or planned clinical trials or experience with HDMtx in individual therapy modalities. It is stressed that HDMtx-therapy should solely be given by highly skilled and experienced clinical oncologists, who are able to prevent toxicity and unnecessary side effects by determining Mtx-serum-levels, urine pH, fluid balance and detect clinical indicators for toxicity early enough to escape fatal organ damages.
Related Concept Videos
Treatment Resistant Cancers
Clinical Trials
There are four phases in a clinical trial. A phase one...
Therapeutic Drug Monitoring: Affecting Factors
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase