Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antibacterial substances in prostatic fluid

W R Fair, R F Parrish

Progress in Clinical and Biological Research

|January 1, 1981

Summary

This summary is machine-generated.

Free zinc in prostatic fluid acts as a natural antibacterial agent, protecting the male urinary tract from infection. Measuring zinc levels may help diagnose and treat prostatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cytokine gene modification of bladder cancer cells for the establishment of bladder cancer vaccine.

International journal of urology : official journal of the Japanese Urological Association·2013

Same author

Introduction--translational research trends: urologic gene therapy.

Molecular urology·2002

Same author

Spectrum-analysis and neural networks for imaging to detect and treat prostate cancer.

Ultrasonic imaging·2002

Same author

Growth of heterotopic LNCaP prostate cancer tumor in nude mice is not affected by dietary calcium.

The Prostate·2001

Same author

Overview consensus statement.

Urology·2001

Same author

Perspectives on prostate cancer diagnosis and treatment: a roundtable.

Urology·2001

Same journal

DNA homology and chromosome stability: a sensitive yeast genetic system for identifying double-stranded DNA damage.

Progress in clinical and biological research·2018

Same journal

Endotoxin and sepsis: molecular mechanisms of pathogenesis, host resistance, and therapy. Proceedings of the 4th Conference of the International Endotoxin Society. Nagoya, Japan, October 23-27, 1996.

Progress in clinical and biological research·1998

Same journal

The pathogenic role of LBP in gram-negative sepsis and septic shock.

Progress in clinical and biological research·1998

Same journal

The role of interleukin 6 in endotoxin-induced inflammatory responses.

Progress in clinical and biological research·1998

Same journal

Role of nitric oxide and reactive oxygen species in endotoxin shock.

Progress in clinical and biological research·1998

Same journal

Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.

Progress in clinical and biological research·1998

See all related articles

Area of Science:

Urology
Microbiology
Biochemistry

Background:

The male urinary tract possesses natural resistance to bacterial infections.
Prostatic fluid is known to exhibit antibacterial properties.

Observation:

The specific factor responsible for the antibacterial activity of normal prostatic fluid was investigated.
The concentration of zinc in prostatic fluid was analyzed in healthy individuals and patients with prostatitis.

Findings:

Free zinc has been identified as the prostatic antibacterial factor responsible for the antibacterial activity of normal prostatic fluid.
The antibacterial efficacy of prostatic fluid correlates with its zinc content, suggesting a role in urinary tract resistance.
Significantly decreased zinc levels were observed in prostatic fluid from patients with bacterial prostatitis.

Related Experiment Videos

Implications:

Zinc levels in expressed prostatic secretions may serve as a diagnostic marker for chronic bacterial prostatitis and susceptibility.
Further research into factors affecting prostatic zinc levels and therapeutic strategies to alter them is warranted for prostatitis treatment and prevention.