Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostacyclin can either increase or decrease heart rate depending on the basal state

M Chiavarelli, S Moncada, K M Mullane

    British Journal of Pharmacology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Brincidofovir treatment of acyclovir-resistant disseminated varicella zoster virus infection in an immunocompromised host.

    Transplant infectious disease : an official journal of the Transplantation Society·2016
    Same author

    Severity of aortic stenosis predicts early post-operative normalization of left atrial size and function detected by myocardial strain.

    International journal of cardiology·2012
    Same author

    Mitral annular longitudinal function preservation after mitral valve repair: the MARTE study.

    International journal of cardiology·2011
    Same author

    International, open-label, noncomparative, clinical trial of micafungin alone and in combination for treatment of newly diagnosed and refractory candidemia.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2005
    Same author

    C2 and C0 values for monitoring cyclosporine therapy in stable heart transplant recipients.

    Transplantation proceedings·2005
    Same author

    Risk factors for smoking abuse after heart transplantation.

    Transplantation proceedings·2004
    Same journal

    Peripheral targets for neuropathic pain.

    British journal of pharmacology·2026
    Same journal

    Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

    British journal of pharmacology·2026
    Same journal

    The role of protein arginine methyltransferases in sickle cell-mediated neurovascular impairments in mice.

    British journal of pharmacology·2026
    Same journal

    β-Cyclodextrin inclusion enhances the pro-resolving effects of the annexin A1 mimetic Ac2-26 in a mouse model of antigen-induced arthritis.

    British journal of pharmacology·2026
    Same journal

    Ursodeoxycholic acid inhibits platelet activation and thrombosis via TREM2: Evidence from mouse models and human studies.

    British journal of pharmacology·2026
    Same journal

    Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery.

    British journal of pharmacology·2026
    See all related articles

    Prostacyclin (PGI2) causes tachycardia in dogs with low heart rates but bradycardia at higher rates or doses. This effect, along with prostaglandin E2 and bradykinin responses, depends on basal heart rate and vagal nerve activity.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Prostacyclin (PGI2) is a potent vasodilator.
    • Its effects on heart rate can be variable.
    • Understanding these effects is crucial for cardiovascular drug development.

    Purpose of the Study:

    • To investigate the influence of basal heart rate on prostacyclin (PGI2)-induced heart rate changes in anesthetized beagles.
    • To compare the effects of PGI2 with prostaglandin E2 (PGE2) and bradykinin on heart rate.
    • To explore the role of the vagal nerve in mediating these responses.

    Main Methods:

    • Anesthetized beagles were used to study heart rate responses.
    • Basal heart rate was manipulated using isoprenaline or nitroprusside.
    • Varying doses of PGI2 were administered intravenously.

    Related Experiment Videos

  • Effects of PGE2 and bradykinin were also assessed.
  • Bilateral vagotomy was performed to assess vagal nerve involvement.

    • Main Results:

    • PGI2 induced tachycardia with hypotension in dogs with low basal heart rates (<100 bpm).
    • PGI2 induced bradycardia with hypotension in dogs with elevated basal heart rates (>130 bpm) or at higher PGI2 doses.
    • Female beagles showed less sensitivity to PGI2-induced reflex bradycardia compared to males.
    • Bradycardia induced by PGI2, PGE2, and bradykinin was reversed by bilateral vagotomy.
    • A correlation was observed between the ability of PGI2, PGE2, and bradykinin to induce bradycardia.

    Conclusions:

    • PGI2-induced bradycardia is dependent on both the dose administered and the basal heart rate.
    • The effects of PGE2 and bradykinin on heart rate are also influenced by the basal heart rate.
    • A common vagal-mediated mechanism may underlie the bradycardic effects of PGI2, PGE2, and bradykinin.