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Activity analysis of operant behavior following methylphenidate administration

G B Freeman, R B Wallace, J Werboff

Perceptual and Motor Skills

|August 1, 1978

Summary

Methylphenidate (a central nervous system stimulant) reduced response rates in rats on a reinforcement schedule. However, it also increased unrelated activity, suggesting a need to analyze both operant and total activity.

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Area of Science:

Neuroscience
Pharmacology
Behavioral Science

Background:

Methylphenidate is a central nervous system stimulant.
Previous research indicates methylphenidate reduces response rates.

Purpose of the Study:

To investigate the effects of methylphenidate on operant behavior and activity in rats.
To analyze how methylphenidate influences response time and activity unrelated to bar pressing.

Main Methods:

13 male Long-Evans hooded rats were used.
Rats were tested under a CRF-50 reinforcement schedule.
Methylphenidate (1.2 mg/kg, intraperitoneally) was administered.

Main Results:

Methylphenidate significantly influenced total response time and activity away from the bar.
Response rates were generally reduced, supporting previous findings.
Non-operant activity significantly increased following methylphenidate administration.

Conclusions:

Methylphenidate's effects on behavior are complex, impacting both operant and non-operant activity.
Analysis of methylphenidate's behavioral effects should consider total activity, not just operant rates.