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Cortisol's effects on human mental functioning

W T Carpenter, P H Gruen

    Journal of Clinical Psychopharmacology
    |April 1, 1982
    PubMed
    Summary
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    See all related articles

    This review explores how cortisol, a stress hormone, impacts mood and behavior. It covers cortisol

    Area of Science:

    • Endocrinology and Neurobiology
    • Stress Physiology
    • Psychopharmacology

    Background:

    • The dexamethasone suppression test highlights the link between cortisol levels and psychological states.
    • Understanding cortisol's role is crucial for mood and behavior research.

    Purpose of the Study:

    • To review the biochemistry, physiology, and pharmacology of cortisol and related compounds.
    • To examine how external stressors affect cortisol metabolism and its daily rhythm.
    • To discuss clinical management of excess cortisol.

    Main Methods:

    • Literature review of existing research on cortisol.
    • Analysis of biochemical pathways and physiological responses.
    • Examination of pharmacological effects and clinical case studies.

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    Main Results:

    • Cortisol's complex interactions with mood and behavior are influenced by metabolism and stress.
    • Circadian rhythms significantly affect cortisol secretion patterns.
    • Exogenous cortisol can lead to specific clinical manifestations.

    Conclusions:

    • Cortisol plays a significant role in regulating mood and behavior.
    • Stress and disrupted circadian rhythms can alter cortisol metabolism.
    • Effective clinical strategies exist for managing cortisol excess.