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Structure and function of mucus

A Silberberg, F A Meyer

    Advances in Experimental Medicine and Biology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Mucus structure is based on a common glycoprotein unit with a protein backbone. This unit forms large aggregates via disulfide bonds, influencing mucus

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    Area of Science:

    • Biochemistry
    • Biophysics
    • Materials Science

    Background:

    • Mucus exhibits complex rheological properties crucial for its biological functions.
    • Understanding the molecular structure of mucus is key to explaining its gel-like behavior.

    Purpose of the Study:

    • To propose a unified model for mucus structure based on available evidence.
    • To elucidate the role of glycoproteins in determining mucus rheology.

    Main Methods:

    • Review and synthesis of existing experimental data on mucus composition and structure.
    • Analysis of the contribution of glycoprotein units and their cross-linking to aggregate formation.

    Main Results:

    • Evidence suggests a basic glycoprotein unit with a conserved protein backbone and variable carbohydrate chains.

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  • Large mucus aggregates (10-100 million molecular weight) form via disulfide bonds and lectin-like interactions.
  • Glycoprotein concentration is a critical determinant of mucus rheological properties.

    • Conclusions:

    • A model of mucus structure based on self-assembling glycoprotein units is supported by current evidence.
    • This structural model provides a framework for understanding mucus function across different species and organs.