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Selenium bioavailability with reference to human nutrition

V R Young, A Nahapetian, M Janghorbani

    The American Journal of Clinical Nutrition
    |May 1, 1982
    PubMed
    Summary

    Understanding selenium bioavailability is crucial for human nutrition. Research highlights the need for more human studies on how food sources and chemical forms of selenium impact its use by the body.

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    Area of Science:

    • Nutritional Biochemistry
    • Human Metabolism

    Background:

    • Limited research exists on selenium metabolism in healthy human subjects.
    • Animal studies indicate factors like selenium source and chemical form affect bioavailability, but human relevance is unclear.

    Purpose of the Study:

    • To review selenium metabolism and nutrition, focusing on bioavailability in human diets.
    • To identify knowledge gaps regarding factors influencing dietary selenium utilization in humans.

    Main Methods:

    • Review of existing literature on selenium metabolism and nutrition.
    • Analysis of animal studies and limited human data.
    • Exploration of stable isotope techniques for human studies.

    Main Results:

    • Animal data suggests bioavailability varies with selenium source and form.
    • Human studies indicate potential differences in the metabolism of selenite versus selenomethionine.
    • Current knowledge on human selenium bioavailability is insufficient.

    Conclusions:

    • More research is essential to understand dietary selenium bioavailability's significance for human health.
    • Stable selenium isotopes show promise for elucidating factors affecting selenium utilization in humans.

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