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Transepithelial potential during strontium-induced spontaneous sweating

K Sato, F Sato

    The American Journal of Physiology
    |May 1, 1982
    PubMed
    Summary
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    Strontium (Sr2+) can trigger sweat secretion in rhesus monkey palm eccrine sweat glands by entering cells, bypassing normal signaling. This process is reversible with calcium (Ca2+).

    Area of Science:

    • Physiology
    • Cell Biology
    • Dermatology

    Background:

    • Eccrine sweat glands regulate body temperature through secretion.
    • The role of specific ions like strontium in sweat gland function is not fully understood.
    • Understanding sweat gland physiology is crucial for thermoregulation research.

    Purpose of the Study:

    • To investigate the effect of strontium (Sr2+) on transepithelial electrical potential difference (PD) in rhesus monkey palm eccrine sweat glands.
    • To explore the mechanism of Sr2+-induced spontaneous sweat secretion (SSS).
    • To compare the effects of Sr2+ with the standard secretagogue methacholine (MCH).

    Main Methods:

    • Measurement of transepithelial electrical potential difference (PD) in isolated sweat gland segments.

    Related Experiment Videos

  • Experiments conducted in calcium (Ca2+)-containing (control) and Ca2+-free Sr2+ media.
  • Varying concentrations of Sr2+ and MCH were used to assess dose-dependent effects.
  • Assessment of the reversibility of Sr2+-induced effects by Ca2+ addition.

    • Main Results:

    • In control medium, MCH induced a lumen-negative PD, saturating at -6 mV.
    • In Sr2+ medium, spontaneous lumen-negative PD developed, mirroring SSS kinetics.
    • The Sr2+-induced PD was dose-dependent, plateauing at -9 mV with 8 mM Sr2+.
    • MCH addition in Sr2+ medium rapidly increased the PD.
    • Ca2+ addition abolished both Sr2+-induced PD and SSS.

    Conclusions:

    • Sr2+ induces true secretory processes in eccrine sweat glands, likely via ion leakage into the cell.
    • This mechanism bypasses normal receptor-agonist interactions.
    • Calcium ions play a critical role in regulating sweat secretion, both in normal and Sr2+-stimulated conditions.