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Antibiotic sensitivity testing: correlations between in vitro tests in vivo situations
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1981
Summary
In vitro antibiotic sensitivity tests don't always predict treatment success in patients. Clinical outcomes depend on factors like drug concentration at infection sites, especially with resistant bacteria.
Area of Science:
- Microbiology
- Pharmacology
- Clinical Medicine
Background:
- In vitro antibiotic sensitivity testing is a cornerstone of antimicrobial stewardship.
- Predicting clinical efficacy from laboratory data remains a challenge.
Purpose of the Study:
- To review the correlation between in vitro antibiotic sensitivity test results and in vivo clinical outcomes.
- To identify factors influencing the reliability of in vitro testing.
Main Methods:
- Literature review of studies correlating in vitro antibiotic susceptibility data with clinical treatment results.
- Analysis of specific cases, including infections with acquired bacterial resistance.
Main Results:
- Correlation between in vitro results and clinical outcomes is not always direct.
- Blood levels and minimal inhibitory concentrations (MICs) are not universally applicable sensitivity criteria.
- Exceptions include local treatments and infections in antibiotic-concentrating body sites.
- Discrepancies observed in infections with resistant bacteria.
Conclusions:
- In vitro antibiotic sensitivity testing requires careful interpretation in clinical practice.
- Factors such as drug distribution and bacterial resistance significantly impact treatment success.
- Special considerations are needed for intestinal bacteria and antibacterials used for growth promotion.