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Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement
Cancer
|July 15, 1982
Summary
Adults with non-Hodgkin's lymphoma presenting with large mediastinal masses often have poor prognoses. This aggressive lymphoma subtype, predominantly large cell, shows limited survival despite intensive treatment.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Non-Hodgkin's lymphoma can present with large mediastinal masses.
- This presentation is often associated with aggressive disease and poor outcomes.
Purpose of the Study:
- To describe the clinical and pathological features of non-Hodgkin's lymphoma patients with large mediastinal masses.
- To evaluate the prognosis of this specific patient subset.
Main Methods:
- Retrospective analysis of 11 adult patients with non-Hodgkin's lymphoma and symptomatic large mediastinal masses.
- Exclusion of patients with lymphoblastic lymphoma.
- Histopathological classification using the Lukes and Collins scheme.
Main Results:
- Most patients were young women with localized disease.
- Tumors were predominantly diffuse large cell lymphomas.
- Median survival was 16 months, with 9 of 11 patients dying within 26 months.
- Sclerosis was noted in four cases.
Conclusions:
- Non-Hodgkin's lymphomas presenting as symptomatic large mediastinal masses, particularly diffuse large cell types, represent a poor prognosis subset.
- Aggressive therapy yielded limited long-term survival in this cohort.