Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biological control of lymphokine function

T Yoshida, S Cohen

    Federation Proceedings
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Immune desensitization suppresses hypersensitivity via multiple lymphokine-dependent mechanisms. These include mediator gradient loss, effector cell preemption, prostaglandin inhibition, and suppressor cell induction, crucial for immune regulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The pathogenesis of gastroesophageal reflux disease: a challenge in clinical physiology.

    Annals of internal medicine·1992
    Same author

    Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia.

    Journal of cellular physiology·1992
    Same author

    The future of gastrointestinal practice and education: self-regulation or governmental control?

    Gastroenterology·1992
    Same author

    Adverse effects of epidural 0.03% bupivacaine during analgesia after cesarean section.

    Anesthesia and analgesia·1992
    Same author

    Dysgonic fermenter-3: a bacterium associated with diarrhea in immunocompromised hosts.

    The American journal of gastroenterology·1992
    Same author

    Lymphocyte subset and cellular immune responses to a brief experimental stressor.

    Psychosomatic medicine·1992
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • Lymphokine-dependent reactions are critical in immune responses.
    • These reactions can be biologically controlled and suppressed.
    • Desensitization, a form of immune unresponsiveness, mimics clinical anergy.

    Purpose of the Study:

    • To investigate the lymphokine-dependent mechanisms underlying immune desensitization.
    • To understand how delayed-type hypersensitivity is suppressed.
    • To elucidate regulatory processes in cell-mediated immunity.

    Main Methods:

    • Systemic administration of high-dose antigen to induce desensitization.
    • Analysis of immune suppression in experimental models.
    • Identification of mediator gradients, effector cell dynamics, and cellular signaling pathways.

    Related Experiment Videos

    Main Results:

    • Desensitization involves multiple lymphokine-dependent suppression mechanisms.
    • Initial suppression may result from high circulating lymphokines affecting mediator gradients and effector cells.
    • Later stages involve prostaglandin (PGE1, PGE2) release by activated macrophages inhibiting lymphokines.
    • Lymphokines can also induce suppressor cells, creating feedback inhibition.

    Conclusions:

    • Immune desensitization is regulated by a complex interplay of lymphokine-dependent mechanisms.
    • These mechanisms, including prostaglandin and suppressor cell pathways, are vital for controlling cell-mediated immunity.
    • Understanding these pathways offers insights into immune regulation and anergy.