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Related Experiment Videos

Systematic studies with amoxapine, a new antidepressant

T A Ban, M Fujimori, W M Petrie

    International Pharmacopsychiatry
    |January 1, 1982
    PubMed
    Summary

    Amoxapine, an antidepressant, can be taken once daily, potentially improving compliance and onset of action. Studies show no significant difference in therapeutic or adverse effects compared to divided doses, with clinically insignificant impacts on psychomotor performance.

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    Area of Science:

    • Pharmacology
    • Clinical Psychiatry

    Background:

    • Amoxapine is a tricyclic antidepressant known for its rapid onset of action.
    • The long half-life of its active metabolite, 8-hydroxyamoxapine, suggests potential for once-daily dosing.
    • Once-daily dosing may enhance patient compliance and mitigate adverse effects.

    Purpose of the Study:

    • To evaluate the efficacy and safety of once-daily amoxapine compared to divided doses.
    • To assess the impact of amoxapine on psychomotor performance and its interaction with ethanol.

    Main Methods:

    • A 6-week double-blind clinical trial in 35 hospitalized patients with depressive disorders compared single vs. divided daily amoxapine doses.
    • A second double-blind study in 8 normal male volunteers assessed amoxapine (50, 100 mg) vs. placebo and amitriptyline (50 mg) with/without ethanol using a latin square design.

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    Main Results:

    • No statistically significant differences in overall therapeutic or adverse effects were found between single and divided amoxapine dosing regimens.
    • Onset of therapeutic effect appeared slightly faster with once-daily amoxapine.
    • Amoxapine did not significantly affect motor reflex, visual-motor coordination, or depth perception compared to placebo, and showed no significant interaction with ethanol.

    Conclusions:

    • Once-daily amoxapine dosing is a viable alternative to divided doses, potentially offering faster onset of therapeutic effects.
    • Amoxapine exhibits clinically insignificant effects on psychomotor performance and does not interact significantly with ethanol at the tested doses.