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Induction of chronic bacterial prostatitis in the dog
The Journal of Urology
|June 1, 1982
Summary
Researchers evaluated three methods for inducing chronic bacterial prostatitis in dogs. Direct injection into the prostate gland proved most effective and easiest, causing persistent infection with fewer side effects.
Area of Science:
- Veterinary Medicine
- Urology
- Infectious Diseases
Background:
- Chronic bacterial prostatitis is a challenging condition in canine urology.
- Establishing reliable animal models is crucial for studying prostatitis pathogenesis and treatment.
Purpose of the Study:
- To evaluate and compare three distinct methods for creating chronic bacterial prostatitis in a canine model.
- To determine the efficacy, persistence, and complication rates associated with each induction technique.
Main Methods:
- Method 1: Escherichia coli injection into the prostatic or caudal vesicle artery post-prostate puncture.
- Method 2: Direct prostatic gland injection of E. coli.
- Method 3: E. coli injection into the prostatic urethra with bladder neck occlusion, with and without prostate trauma.
Main Results:
- Direct prostatic injection (Method 2) infected 5/6 dogs, persisting up to 42 days.
- Arterial injection (Method 1) infected 4/5 dogs for up to 28 days.
- Urethral injection (Method 3) showed variable success (2/8 or 5/7 dogs) and shorter persistence (28 days); direct injection was easiest with fewest secondary infections.
Conclusions:
- All three methods successfully induced persistent chronic bacterial prostatitis in dogs.
- Direct prostatic injection of E. coli is the most technically straightforward and results in fewer concurrent urinary tract infections, making it a preferred model.