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The National Cancer Chemotherapy Program

E Frei

    Science (New York, N.Y.)
    |August 13, 1982
    PubMed
    Summary

    The National Cancer Chemotherapy Program has discovered over 30 effective antitumor agents. Advances in science have improved cancer treatment through drug development and clinical trials.

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    Area of Science:

    • Oncology
    • Pharmacology
    • Clinical Trials

    Background:

    • The National Cancer Chemotherapy Program, established in 1955, is managed by the National Cancer Institute's Division of Cancer Treatment.
    • The program focuses on discovering, developing, and testing new antitumor agents.

    Purpose of the Study:

    • To outline the historical development and evolution of the National Cancer Chemotherapy Program.
    • To highlight the program's methodologies in drug discovery, preclinical screening, and clinical trials.
    • To emphasize the impact of scientific advancements on cancer treatment strategies.

    Main Methods:

    • Discovery and development of novel antitumor agents.
    • Preclinical screening for efficacy and toxicology.
    • Phased clinical trials (preliminary and definitive) for selected agents.
    • Integration of research with advances in tumor biology and drug development.

    Main Results:

    • Discovery of over 30 chemotherapeutic agents with significant antitumor activity.
    • Advancement of cancer treatment through the strategic use of these agents, often in combination therapies.
    • Demonstrated progress in the effective management of various cancer types.

    Conclusions:

    • The program has evolved from empirical methods to a science-driven approach, significantly impacting cancer chemotherapy.
    • Effective collaboration between investigator-initiated research and developmental research has been crucial.
    • The program's contributions have led to substantial improvements in cancer patient outcomes.

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