Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonidine hydrochloride

M C Houston

    Southern Medical Journal
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clonidine hydrochloride effectively lowers blood pressure by stimulating alpha-adrenergic receptors, reducing sympathetic tone. This antihypertensive agent is well-tolerated and suitable for diverse patient populations, including those with comorbidities.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study.

    Evidence-based complementary and alternative medicine : eCAM·2008
    Same author

    A free-ranging roundtable discussion on hypertension.

    Journal of human hypertension·2005
    Same author

    Postoperative morbidity in the morbidly obese parturient woman: supraumbilical and low transverse abdominal approaches.

    American journal of obstetrics and gynecology·2000
    Same author

    Alpha 1-blocker combination therapy for hypertension.

    Postgraduate medicine·1998
    Same author

    The effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamil.

    Archives of internal medicine·1995
    Same author

    Hypertension and coronary heart disease risk factor management.

    Australian family physician·1994
    Same journal

    The Five Essential Concepts of Developmental Medicine: A Medical Paradigm for People with Developmental Disabilities.

    Southern medical journal·2026
    Same journal

    α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.

    Southern medical journal·2026
    Same journal

    Association between Main Pancreatic Duct Size, Comorbidities, and Fistula Formation after Whipple Procedure for Pancreatic Cancer.

    Southern medical journal·2026
    Same journal

    Impact of Temperature Variation on Patients with Acute Severe Asthma.

    Southern medical journal·2026
    Same journal

    Assessing the Accuracy and Reliability of ChatGPT-4 to Answer Clinical EHR Messages in Sports Medicine.

    Southern medical journal·2026
    Same journal

    Diagnostic Utility and Clinical Implications of Inpatient Fecal Occult Blood Testing.

    Southern medical journal·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Nephrology

    Background:

    • Clonidine hydrochloride (Catapres) has been a clinically utilized antihypertensive agent since 1974.
    • It functions as an alpha-adrenergic receptor agonist, targeting central alpha receptors in the brainstem.
    • Its mechanism involves diminishing efferent sympathetic tone and increasing vagal activity.

    Purpose of the Study:

    • To review the pharmacological and clinical profile of clonidine hydrochloride as an antihypertensive agent.
    • To elucidate its hemodynamic and renal effects in managing hypertension.
    • To assess its safety, efficacy, and role in combination therapy.

    Main Methods:

    • Review of existing clinical data and pharmacological studies on clonidine.

    Related Experiment Videos

  • Analysis of hemodynamic parameters including blood pressure, heart rate, and cardiac output.
  • Evaluation of renal function and hormonal excretion patterns.

    • Main Results:

    • Clonidine significantly reduces mean arterial pressure in various degrees of hypertension, both acutely and chronically.
    • It demonstrates minimal tolerance development and postural hypotension.
    • The drug is well-tolerated, with over 93% of patients showing good tolerance; common side effects like sedation and dry mouth are manageable.

    Conclusions:

    • Clonidine hydrochloride is a versatile and effective antihypertensive medication.
    • It offers significant blood pressure reduction with a favorable safety profile, even in patients with comorbidities.
    • Its efficacy is enhanced with diuretics or vasodilators, offering an alternative to beta-blockers in certain combinations.