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Related Experiment Videos

Ejection fraction derived using dye dilution and angiographic methods

W J French, D Garner, D Hockett

    American Heart Journal
    |July 1, 1982
    PubMed
    Summary
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    Ventriculography often overestimates left ventricular ejection fraction (EF-V). A new method using green dye to determine stroke volume (SV) with ventriculography-derived end-diastolic volume (EDV) provides a more accurate correlated ejection fraction (EF-C).

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Physiology

    Background:

    • Left ventricular ejection fraction (EF-V) measured by ventriculography is standard for assessing cardiac function.
    • Inaccurate end-systolic volume (ESV) measurements due to irregular ventricular geometry can lead to significant errors in EF-V.
    • Dilution methods offer more accurate stroke volume (SV) determination compared to ventriculography.

    Purpose of the Study:

    • To develop an improved method for calculating left ventricular (LV) ejection fraction.
    • To assess a correlated ejection fraction (EF-C) using ventriculography-derived end-diastolic volume (EDV) and green dye-derived SV.
    • To investigate discrepancies in cardiac output (CO) calculations between dilution methods and ventriculography.

    Main Methods:

    • Cardiac output (CO) was measured in eight anesthetized dogs using both green dye dilution and left ventriculography.

    Related Experiment Videos

  • End-diastolic volume (EDV) was determined via ventriculography.
  • Stroke volume (SV) was calculated using green dye dilution, and then used to derive a correlated ejection fraction (EF-C).

    • Main Results:

    • Ventriculography-derived CO was significantly higher than green dye-derived CO (p < 0.005).
    • Ventriculographically derived ejection fraction (EF-V) was consistently higher than the correlated ejection fraction (EF-C) (55 ± 15% vs. 32 ± 12%, p < 0.005).

    Conclusions:

    • The study highlights potential reasons for discrepancies in CO measurements between dilution techniques and ventriculography.
    • A novel method is presented to enhance the accuracy of LV ejection fraction calculation by integrating green dye SV with ventriculographic EDV.
    • This approach may lead to more precise assessments of left ventricular function.