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Updated: Aug 12, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Phase II trial of piperazinedione in metastatic sarcoma
Abstract:
Thirty-five patients with metastatic sarcomas received piperazinedione 9 mg/m2 every 3 weeks. Of 27 evaluable patients, 3 patients had stable disease for at least 6 weeks. The dose-limiting toxicity was myelosuppression. Piperazinedione is inactive in patients with drug-resistant metastatic sarcomas.
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