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A model of the mesenteric circulation

E D Jacobson, R H Gallavan, J D Fondacaro

    The American Journal of Physiology
    |June 11, 1982
    PubMed
    Summary
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    A new model explains intestinal hyperemia by proposing a two-component microcirculation. This model differentiates responses to various stimuli, impacting blood flow and oxygen consumption in the small intestine.

    Area of Science:

    • Physiology
    • Gastroenterology
    • Microcirculation

    Background:

    • The mesenteric microcirculation's response to stimuli is complex.
    • Understanding intestinal hyperemia is crucial for metabolic regulation.

    Purpose of the Study:

    • To propose a model of mesenteric microcirculation explaining three types of hyperemic responses.
    • To differentiate the roles of flow-independent and flow-limited components in intestinal blood flow regulation.

    Main Methods:

    • Development of a theoretical model of a two-component mesenteric microcirculation.
    • Analysis of three distinct hyperemic responses to pharmacological and physiological stimuli.

    Main Results:

    • The model differentiates hyperemia based on whether flow-limited or flow-independent components are affected.

    Related Experiment Videos

  • Drug-induced hyperemia (nifedipine, acetylcholine) affects only the flow-limited component.
  • Nutrient cotransport stimulates the flow-independent component, increasing oxygen consumption disproportionately.
  • Adenosine-induced hyperemia dilates both components, with blood flow increasing more than oxygen consumption.

    • Conclusions:

    • The two-component model successfully explains varied intestinal hyperemic responses.
    • Different stimuli differentially engage vascular components, leading to distinct blood flow and oxygen consumption patterns.
    • This model provides insight into the regulation of intestinal metabolism and blood flow.