Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Barrett's esophagus

E M Bozymski, K J Herlihy, R C Orlando

    Annals of Internal Medicine
    |July 1, 1982
    PubMed
    Summary

    Barrett's esophagus is an acquired condition caused by chronic acid reflux, where the esophagus lining changes. Early detection and monitoring are crucial for preventing esophageal adenocarcinoma.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.

    Mucosal immunology·2013
    Same author

    Markers of tyrosine kinase activity in eosinophilic esophagitis: a pilot study of the FIP1L1-PDGFRα fusion gene, pERK 1/2, and pSTAT5.

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2011
    Same author

    Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21-23 April 2010.

    Alimentary pharmacology & therapeutics·2011
    Same author

    Mechanisms of increased esophageal sensitivity.

    Postgraduate medicine·2009
    Same author

    Physicochemical basis for dilated intercellular spaces in non-erosive acid-damaged rabbit esophageal epithelium.

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2008
    Same author

    Nonerosive reflux disease.

    Minerva gastroenterologica e dietologica·2007

    Area of Science:

    • Gastroenterology
    • Oncology
    • Pathology

    Background:

    • Barrett's esophagus is characterized by the replacement of normal esophageal stratified squamous epithelium with columnar epithelium.
    • Historically misattributed to congenital short esophagus, it is now understood as an acquired condition.
    • Chronic gastroesophageal reflux is the established cause of Barrett's esophagus.

    Purpose of the Study:

    • To define Barrett's esophagus and its diagnostic criteria.
    • To outline the complications and significance of Barrett's esophagus.
    • To discuss current treatment strategies and controversies.

    Main Methods:

    • Definitive diagnosis relies on endoscopy with directed biopsies.
    • Biopsies identify columnar epithelium above the lower esophageal sphincter.
    • Histological examination reveals three epithelial types: gastric-fundic, junctional, and specialized columnar.

    Main Results:

    • Barrett's esophagus is associated with esophageal strictures and ulcers.
    • The primary significance lies in its association with esophageal adenocarcinoma development.
    • The cellular origin of the altered epithelium remains under investigation.

    Conclusions:

    • Management focuses on controlling gastroesophageal reflux and vigilant endoscopic surveillance.
    • Surveillance aims to detect dysplasia and early adenocarcinoma.
    • The necessity of anti-reflux surgery for Barrett's esophagus remains a subject of debate.

    Related Experiment Videos