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Related Experiment Videos

SAA, an apoprotein of HDL: its structure and function

E P Benditt, J S Hoffman, N Eriksen

    Annals of the New York Academy of Sciences
    |January 1, 1982
    PubMed
    Summary

    Serum amyloid protein AA (apoSAA) is part of high-density lipoprotein (HDL) particles. In mice, apoSAA is cleared rapidly, suggesting a unique function possibly involving its C-terminal amino acids.

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    Area of Science:

    • Biochemistry
    • Lipid Metabolism
    • Immunology

    Background:

    • Amyloid protein AA (apoSAA) is a serum apoprotein associated with high-density lipoprotein (HDL) fractions.
    • ApoSAA is found on particles containing apoA-I and C-apoproteins.

    Purpose of the Study:

    • To investigate the association of apoSAA with lipoprotein fractions.
    • To explore the in vivo behavior and potential function of apoSAA.

    Main Methods:

    • Immunoprecipitation using anti-AA antibodies.
    • Isolation of lipoprotein fractions from endotoxin-treated mice.
    • Comparison of plasma clearance rates of apoSAA and apoA-I in mice.

    Main Results:

    • ApoSAA was identified on HDL particles carrying apoA-I and C-apoproteins.

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  • A specific HDL subset with a 2:1 molar ratio of apoSAA to apoA-I was isolated from endotoxin-treated mice.
  • Native apoSAA exhibited a faster clearance rate from plasma than apoA-I in mice.

    • Conclusions:

    • ApoSAA is a component of a distinct subset of HDL particles.
    • The rapid clearance of apoSAA suggests a specialized biological role.
    • The C-terminal region of apoSAA may be crucial for its function.