Moraxella corneal ulcers: poor response to medical treatment

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

G A Stern

    Annals of Ophthalmology
    |March 1, 1982
    PubMed

    Insights

    Chronic alcoholics with Moraxella corneal ulcers often require surgery despite medical treatment. Host factors likely contribute to poor outcomes in these serious eye infections.

    Area of Science:

    • Ophthalmology
    • Microbiology

    Background:

    • Corneal ulcers are a significant cause of vision loss.
    • Moraxella species are Gram-negative bacteria that can cause ocular infections.

    Observation:

    • Three chronic alcoholic patients presented with corneal ulcers.
    • Diagnosis was confirmed by Gram's stain and culture.
    • All patients required surgical intervention despite medical management.

    Findings:

    • Moraxella species were identified as the causative agents.
    • Surgical interventions included penetrating keratoplasty and conjunctival flap.
    • In vitro antibiotic susceptibility did not correlate with clinical response.

    Implications:

    • Moraxella corneal ulcers in chronic alcoholics have a poor prognosis.
    • Host factors, potentially related to alcoholism, may impair healing.
    • Further research into host-pathogen interactions is warranted.

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