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Evaluation of flurazepam and placebo on sleep disorders in childhood

R Reimão, A B Lefévre

    Arquivos De Neuro-Psiquiatria
    |March 1, 1982
    PubMed

    Insights

    Flurazepam significantly improved sleepwalking, sleep-talking, bruxism, sleep terror, and excessive movements in children. Some patients experienced side effects like daytime drowsiness.

    Area of Science:

    • Pediatric Sleep Medicine
    • Clinical Pharmacology

    Background:

    • Sleep disturbances are common in children.
    • Investigating effective treatments for pediatric sleep disorders is crucial.

    Purpose of the Study:

    • To evaluate the efficacy and safety of flurazepam in treating sleep disturbances in children.
    • To compare flurazepam's effects against a placebo.

    Main Methods:

    • A randomized, placebo-controlled study involving 40 pediatric patients (1-15 years old).
    • Patients received flurazepam (15mg daily) or placebo for 14 days each, in a crossover design.
    • Evaluated chief complaints including sleepwalking, sleep-talking, sleep terror, bruxism, headbanging, insomnia, and excessive movements.

    Main Results:

    • Flurazepam demonstrated significant efficacy in reducing sleepwalking, sleep-talking, bruxism, sleep terror, and excessive movements.
    • Side effects of flurazepam included daytime drowsiness, irritability, and nausea/vomiting.
    • Two cases required discontinuation due to persistent excessive daytime drowsiness.

    Conclusions:

    • Flurazepam is an effective treatment for several pediatric sleep disturbances.
    • Careful monitoring for side effects, particularly daytime drowsiness, is recommended.
    • Further research is needed for sleep-related headbanging in pediatric populations.

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