Role of the RES in the pathogenesis of endotoxic hypoglycemia

The role of the RES in the alteration of glucose homeostasis was evaluated in male rats treated with S enteritidis endotoxin. Depression of hepatic gluconeogenesis coupled to enhanced peripheral glucose use was substantiated in vivo using the primed-constant infusion technique with 2-3H-D glucose. Immuno-reactive insulin was elevated in the early hyperglycemic phase but declined in endotoxic hypoglycemia. NSILA was elevated in late endotoxin shock. Two monokines--macrophage insulin-like activity (MILA) and macrophage insulin releasing activity (MIRA)--are related to the pathogenesis of endotoxic hypoglycemia.