Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Phenytoin intoxication and serum level]

R Beier, M Zschiesche, R Cammann

    Psychiatrie, Neurologie, Und Medizinische Psychologie
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development of a subacute ruminal acidosis risk score and its prediction using milk mid-infrared spectra in early-lactation cows.

    Journal of dairy science·2021
    Same author

    Allogeneic-matched sibling stem cell transplantation in a 13-year-old boy with ataxia telangiectasia and EBV-positive non-Hodgkin lymphoma.

    Bone marrow transplantation·2016
    Same author

    Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia.

    Klinische Padiatrie·2015
    Same author

    Minimal antileukaemic treatment followed by reduced-intensity conditioning in three consecutive children with Fanconi anaemia and AML.

    Bone marrow transplantation·2014
    Same author

    Prediction of outcome by early response in childhood acute lymphoblastic leukemia.

    Klinische Padiatrie·2013
    Same author

    Key treatment questions in childhood acute lymphoblastic leukemia: results in 5 consecutive trials performed by the ALL-BFM study group from 1981 to 2000.

    Klinische Padiatrie·2013
    Same journal

    [Comments on psychosomatic manifestations in ophthalmology].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    Same journal

    [Symptomatic myasthenia as a paraneoplastic syndrome in mixed-cell myelosis?].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    Same journal

    [Action and reaction elements as performance-modifying components of computer use in clinical psychology].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    Same journal

    [Clinical multiplicity of cerebrovascular disorders in childhood].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    Same journal

    [Endogenous psychoses in relation to absent phenylalanine hydroxylase activity in thrombocytes].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    Same journal

    [Pathology of inflammatory diseases of the central nervous system--an autopsy analysis 1967-1988].

    Psychiatrie, Neurologie, und medizinische Psychologie·1990
    See all related articles

    Phenytoin intoxication affects 8.4% of adults and 9.5% of children, primarily causing cerebellar symptoms. Significant interindividual variability exists in toxic phenytoin levels, though intraindividual levels correlate with symptoms.

    Area of Science:

    • Pharmacology
    • Clinical Toxicology
    • Neurology

    Context:

    • Phenytoin is a widely used antiepileptic drug.
    • Monitoring therapeutic drug levels is crucial for efficacy and safety.
    • Intoxication can lead to significant adverse effects, particularly neurological.

    Purpose:

    • To investigate the clinical presentation and serum concentrations associated with phenytoin intoxication.
    • To explore the variability in toxic thresholds for phenytoin.
    • To understand the pharmacokinetic profile of phenytoin elimination after withdrawal.

    Summary:

    • Phenytoin intoxication was observed in 8.4% of adult and 9.5% of pediatric patients, with cerebellar symptoms being most common.
    • Serum phenytoin concentrations ranged from 14.4 to 77.7 microgram/ml.

    Related Experiment Videos

  • Significant interindividual variability in toxic levels was noted; one-third of patients with levels >20 microgram/ml were asymptomatic, and one patient tolerated >30 microgram/ml.
  • Intraindividual toxicity correlated with serum concentration, which decreased exponentially after drug withdrawal.
  • Elimination half-life ranged from 72 to 122 hours.

    • Impact:

    • Highlights the wide interindividual variability in phenytoin toxicity, suggesting personalized therapeutic drug monitoring.
    • Emphasizes the importance of correlating clinical symptoms with serum concentrations for accurate diagnosis of phenytoin intoxication.
    • Provides pharmacokinetic data on phenytoin elimination, aiding in management post-intoxication.