Biochemistry of alkaline phosphatase isoenzymes

The review discusses the similarities and differences between the common isoenzymatic forms of ALP. Methods for separating, measuring, and purifying the isoenzymes on the basis of these differing properties are described. The evidence is reviewed for the existence of different genes coding for different isoenzymes, and the current state of knowledge is surveyed concerning the location, development, function, and regulation of the isoenzymes. Finally, some unusual forms of ALP which may appear in the circulation are described.