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[Sensitivity in vitro of some bacterial strains to procaine]
Abstract:
The action range of procaine, this multipotent substance, may also be extended to the domain of bacteriology due to its bacteriostatic, bactericide, fungistatic and fungicide properties. The antibacterial activity of Höechst procaine hydrochlorate powder was determined on 15 bacterial strains and 2 Candida strains isolated from various human infections. The in vitro antibacterial effect of the powder was demonstrated by the diffusimetric and the dilution methods, determining the minimal inhibitory concentration and minimal bactericide concentration. Procaine had a high antibacterial activity against Streptococcus B hemolyticus gr. A and viridans, and against certain enterobacteria (E. coli Proteus). THe results show the possibility of using procaine also in the local treatment of infections caused by these agents.
Insights
Procaine exhibits significant antibacterial and antifungal properties. This study demonstrates its effectiveness against various human pathogens, suggesting potential for treating local infections.
Area of Science:
- Bacteriology
- Pharmacology
- Mycology
Background:
- Procaine, a known substance, possesses bacteriostatic, bactericidal, fungistatic, and fungicidal properties.
- Its potential applications extend to the field of bacteriology.
Purpose of the Study:
- To determine the antibacterial activity of Höechst procaine hydrochloride powder.
- To evaluate its efficacy against bacterial and Candida strains from human infections.
Main Methods:
- In vitro assessment using diffusimetric and dilution methods.
- Determination of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
- Testing against 15 bacterial strains and 2 Candida strains.
Main Results:
- Procaine demonstrated high antibacterial activity against Streptococcus B hemolyticus gr. A and viridans.
- Effective against certain enterobacteria, including E. coli and Proteus.
- Antifungal activity was also observed against Candida strains.
Conclusions:
- Procaine hydrochloride exhibits significant antimicrobial effects in vitro.
- Results support the potential use of procaine in the local treatment of specific bacterial and fungal infections.