Acyclovir therapy in cutaneous herpes simplex following bone marrow transplantation. A case report

Herpes simplex virus was demonstrated in rapidly progressing cutaneous lesions 7 days after allogeneic bone marrow transplantation in a 14-year-old girl. Extension of the eruption was not controlled by hyperimmune plasma and transfer factor. In contrast, prompt and complete resolution followed administration of acyclovir. The absence of renal insufficiency or damage to the new graft emphasizes the value of this agent in managing progressive herpes simplex infections in immunocompromised patients.