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Doxycycline

B A Cunha, C M Sibley, A M Ristuccia

    Therapeutic Drug Monitoring
    |January 1, 1982
    PubMed
    Summary

    Doxycycline is a versatile antibiotic with broad-spectrum antimicrobial activity. Its favorable pharmacokinetics, including excellent tissue penetration and once-daily dosing, support its efficacy in treating various infections and preventing traveler's diarrhea.

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    Postgraduate medicine·2016

    Area of Science:

    • Pharmacology
    • Microbiology
    • Infectious Diseases

    Background:

    • Doxycycline is a well-established antibiotic.
    • Understanding its comprehensive profile is crucial for clinical application.

    Purpose of the Study:

    • To review the chemistry, mode of action, antimicrobial activity, pharmacokinetics, and therapeutic efficacy of doxycycline.
    • To consolidate existing knowledge on doxycycline's clinical utility.

    Main Methods:

    • Review of existing literature on doxycycline.
    • Analysis of data on antimicrobial spectrum, absorption, distribution, metabolism, excretion, and clinical outcomes.

    Main Results:

    • Doxycycline exhibits broad-spectrum activity against gram-positive and gram-negative aerobic and anaerobic pathogens.
    • Rapid and complete oral absorption, comparable serum concentrations with oral and intravenous administration, and a prolonged half-life enable once-daily dosing.
    • Excellent tissue penetration into various organs and tissues.
    • No accumulation in renal insufficiency; minimal removal during hemodialysis.
    • High efficacy demonstrated in respiratory tract infections, skin and soft tissue infections, genitourinary infections, intra-abdominal infections, and cholera.
    • Evidence suggests effectiveness against Legionnaires' disease and prevention of traveler's diarrhea.

    Conclusions:

    • Doxycycline is a highly effective antibiotic with favorable pharmacokinetic properties.
    • Its broad spectrum of activity and excellent tissue penetration make it suitable for a wide range of infections.
    • Doxycycline is a valuable therapeutic option for numerous bacterial infections and prophylaxis.

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