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Related Experiment Videos

[The value of fosfomycin]

C Tauchnitz, R Ezold, J Gonschorek

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |May 1, 1982
    PubMed
    Summary

    Fosfomycin demonstrates high effectiveness against common pathogens like E. coli and Staph. aureus. This antibiotic shows promise as a valuable addition to therapeutic options, warranting further clinical investigation.

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    Area of Science:

    • Pharmacology and Microbiology

    Background:

    • Fosfomycin is an antibiotic with notable pharmacokinetic and antibacterial properties.
    • Clinical experiences with fosfomycin have been documented.

    Purpose of the Study:

    • To determine the resistance patterns of common clinical pathogens to fosfomycin.
    • To evaluate the antibacterial activity of fosfomycin in various strains.

    Main Methods:

    • Disk diffusion tests were employed to assess bacterial susceptibility.
    • Tests included a platelet content of 20 micrograms with glucose-6-phosphate admixture.

    Main Results:

    • High sensitivity rates were observed in E. coli, P. mirabilis, Haemophilus influenzae, and Staphylococcus aureus.
    • Many Klebsiella and Pseudomonas strains also exhibited sensitivity.
    • Streptococci, pneumococci, and enterococci were predominantly resistant.

    Conclusions:

    • Fosfomycin exhibits a narrower spectrum in oral therapy compared to high-dose parenteral administration.
    • Fosfomycin represents a valuable therapeutic option in both oral and parenteral forms.
    • Further clinical studies are recommended to fully explore its therapeutic potential.

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