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Blastomycosis

M J Tenenbaum, J Greenspan, T M Kerkering

    Critical Reviews in Microbiology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Blastomycosis, a fungal infection, is caused by Blastomyces dermatitidis. Recent findings reveal it can be self-limiting and presents in new ways, including reactivation and opportunistic infections.

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    Area of Science:

    • Mycology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Blastomycosis is caused by the dimorphic fungus Blastomyces dermatitidis.
    • Previously thought to be limited to North America, Blastomyces dermatitidis is now found in Africa and South America.
    • The fungus's natural habitat remains largely unknown, hindering epidemiological studies.

    Purpose of the Study:

    • To review the current understanding of blastomycosis.
    • To emphasize recent developments in clinical presentations and epidemiology.
    • To highlight the challenges in studying Blastomyces dermatitidis due to difficulties in environmental isolation and diagnostic limitations.

    Main Methods:

    • Literature review focusing on recent developments in blastomycosis.
    • Analysis of case studies, including laboratory infections and common-source epidemics.

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  • Discussion of diagnostic limitations, such as the lack of reliable skin tests and sensitive serological assays.
  • Main Results:

    • Blastomycosis can present as a self-limited pulmonary infection.
    • Endogenous reactivation is a newly recognized clinical manifestation.
    • Opportunistic infections represent another emerging clinical presentation of blastomycosis.

    Conclusions:

    • Understanding of blastomycosis epidemiology and clinical spectrum is limited by diagnostic and environmental challenges.
    • Recent observations suggest blastomycosis has a broader clinical spectrum than previously recognized.
    • Further research is needed to overcome diagnostic hurdles and fully elucidate the epidemiology and clinical diversity of blastomycosis.