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Related Experiment Videos

Methyldopa in the elderly hypertensive

J P MacFarlane

    Current Medical Research and Opinion
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The European Working Party on High Blood Pressure in the Elderly (EWPHE) study found active treatment significantly reduced blood pressure in older adults. However, no significant differences in major health outcomes were observed between active treatment and placebo groups.

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    Area of Science:

    • Gerontology
    • Cardiovascular Medicine
    • Clinical Pharmacology

    Background:

    • Hypertension is a prevalent condition in the elderly population.
    • Effective management of high blood pressure in older adults is crucial for reducing cardiovascular risk.
    • The European Working Party on High Blood Pressure in the Elderly (EWPHE) initiated a study to investigate treatment efficacy.

    Purpose of the Study:

    • To evaluate the effects of antihypertensive treatment on blood pressure, morbidity, and mortality in elderly individuals.
    • To compare the outcomes of active treatment versus placebo in this demographic.

    Main Methods:

    • A 5-year prospective study involving elderly patients.
    • Randomized controlled trial design with two arms: placebo and active treatment.

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  • Active treatment involved hydrochlorothiazide and triamterene, with methyldopa added if necessary.

    • Main Results:

    • A statistically significant reduction in sitting blood pressure was observed in both groups.
    • The reduction in blood pressure was significantly greater in the active treatment group compared to the placebo group.
    • No significant differences were found in morbidity and mortality rates between the active treatment and placebo groups over the 5-year study period.

    Conclusions:

    • Active antihypertensive treatment effectively lowers blood pressure in the elderly.
    • Despite significant blood pressure reduction, active treatment did not lead to statistically significant improvements in morbidity or mortality compared to placebo in this study.
    • The studied antihypertensive regimen was well-tolerated with few side-effects reported.