Two-dose comparison of chlormezanone in sleep disturbance due to anxiety

A double-blind, crossover, multi-centre study was carried out in general practice on 76 patients with mild neurotic anxiety and associated sleep disturbance to compare the effectiveness of chlormezanone given as a single night-time dose of 200 mg or 400 mg, each given for a period of 1 week. There was a significant improvement in the quality and duration of sleep with both dosages, and this was significantly greater with the higher dose. Both doses produced a similarly significant improvement in the frequency of awakening refreshed, and reduction in anxiety rating. The higher dose was considered overall more effective, and significantly more patients preferred it.