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[Lung tissue diffusion of intravenous trimethoprim-sulfamethoxazole combination (author's transl)]
Abstract:
In 13 cases of pneumonectomy, we have studied the concentration of TMP-SMZ in tissue and serum, after three days of treatment. Four hours after TMP-SMZ injection, the tissue's samples obtained from crushed and mixed ; the dosages were performed by a microbiological assay. As we previously described in bronchial secretions : the lung penetration of TMP is important ; the tissue concentrations were higher than in serum ; the diffusion of SMZ is low. The ratio of TMP to SMZ were diffusion of SMZ is low. The ratio of TMP to SMZ were different in serum and tissue, but the antibacterial activity is not affected in vitro by the value's modification.
Insights
Trimethoprim-sulfamethoxazole (TMP-SMZ) shows important lung penetration, with higher tissue concentrations than serum. While sulfamethoxazole diffusion is low, this does not impact the drug
Area of Science:
- Pharmacology
- Microbiology
- Thoracic Surgery
Context:
- Pneumonectomy involves significant lung tissue removal, necessitating careful consideration of antibiotic distribution.
- Optimizing antibiotic therapy in patients undergoing pneumonectomy is crucial for preventing post-operative infections.
Purpose:
- To investigate the tissue and serum concentrations of trimethoprim-sulfamethoxazole (TMP-SMZ) in patients following pneumonectomy.
- To evaluate the lung tissue penetration and diffusion characteristics of TMP and SMZ in this patient population.
Summary:
- In 13 pneumonectomy cases, TMP-SMZ concentrations were measured in lung tissue and serum 4 hours post-administration using microbiological assays.
- Results indicated substantial trimethoprim (TMP) penetration into lung tissue, with concentrations exceeding serum levels.
- Sulfamethoxazole (SMZ) exhibited low diffusion into tissue, and while TMP:SMZ ratios varied between serum and tissue, in vitro testing showed no compromise in antibacterial activity.
Impact:
- This study provides crucial pharmacokinetic data on TMP-SMZ in lung tissue post-pneumonectomy.
- Findings suggest that TMP-SMZ can achieve effective concentrations in lung tissue, potentially aiding in infection prophylaxis or treatment in this surgical context.
- Understanding drug distribution is vital for tailoring antimicrobial strategies in thoracic surgery patients.